abstract：:Motility is required for feeding, reproduction and maintenance of the fluke in the host's liver. According to that, the neuromuscular system can be an attractive drugable target for chemotherapy. Musculature of the Fascioloides magna is organized into three layers, an outer circular layer, beneath this layer the longi...

journal_title：Experimental parasitology

authors： Trailović SM,Marinković D,Trailović JN,Milovanović M,Marjanović DS,Aničić MR

更新日期：2015-12-01 00:00:00

abstract：:Trichomonas vaginalis is a human urogenital pathogen that causes trichomoniasis, the most common nonviral, parasitic sexually transmitted infection in the world. At present, little is known regarding the degree of strain variability of T. vaginalis. A classification method for T. vaginalis strains would be a useful to...

journal_title：Experimental parasitology

authors： Momeni Z,Sadraei J,Kazemi B,Dalimi A

更新日期：2015-12-01 00:00:00

abstract：:Protein tyrosine phosphatase of regenerating liver (PRL) is a group of phosphatases that has not been broadly studied in protozoan parasites. In humans, PRLs are involved in metastatic cancer, the promotion of cell migration and invasion. PTPs have been increasingly recognized as important effectors of host-pathogen i...

journal_title：Experimental parasitology

authors： Ramírez-Tapia AL,Baylón-Pacheco L,Espíritu-Gordillo P,Rosales-Encina JL

更新日期：2015-12-01 00:00:00

abstract：:Entamoeba histolytica programmed cell death (PCD) induced by G418 is characterized by the release of important amounts of intracellular calcium from reservoirs. Nevertheless, no typical caspases have been detected in the parasite, the PCD phenotype is inhibited by the cysteine protease inhibitor E-64. These results st...

journal_title：Experimental parasitology

authors： Monroy VS,Flores OM,García CG,Maya YC,Fernández TD,Pérez Ishiwara DG

更新日期：2015-12-01 00:00:00

abstract：:The aim of this study was to analyze the antioxidant status and oxidative profile in serum and liver of rats experimentally infected with Fasciola hepatica and its relationship with pathological findings. Twenty-four rats were divided into two groups: group A consisted of 12 healthy rats and group B of 12 rats infecte...

journal_title：Experimental parasitology

authors： Bottari NB,Mendes RE,Lucca NJ,Schwertz CI,Henker LC,Olsson DC,Piva MM,Sangoi M,Campos LP,Moresco RN,Jaques JA,Da silva AS

更新日期：2015-12-01 00:00:00

abstract：:The risk of human hookworm infections from land application of wastewater matrices could be high in regions with high hookworm prevalence. A rapid, sensitive and specific hookworm detection method from wastewater matrices is required in order to assess human health risks. Currently available methods used to identify h...

journal_title：Experimental parasitology

authors： Gyawali P,Sidhu JP,Ahmed W,Jagals P,Toze S

更新日期：2015-12-01 00:00:00

abstract：:Tapeworms are pervasive and globally distributed parasites that infect millions of humans and livestock every year, and are the causative agents of two of the 17 neglected tropical diseases prioritized by the World Health Organization. Studies of tapeworm biology and pathology are often encumbered by the complex life ...

journal_title：Experimental parasitology

authors： Rozario T,Newmark PA

更新日期：2015-11-01 00:00:00

abstract：:In C57BL/6 mice, Leishmania donovani infection in the liver provoked IFN-γ-induced expression of the immunity-related GTPases (IRG), Irgm1 and Irgm3. To gauge the antileishmanial effects of these macrophage factors in the liver, intracellular infection was analyzed in IRG-deficient mice. In early- (but not late-) stag...

journal_title：Experimental parasitology

authors： Murray HW,Mitchell-Flack M,Taylor GA,Ma X

更新日期：2015-10-01 00:00:00

abstract：:During its parasitic life stages, the marine ectoparasitic copepod Lepeophtheirus salmonis ingests large amounts of host blood, which contains high amounts of iron. Iron is an essential micronutrient, but also toxic in high dosages, and blood-feeding parasites like the salmon louse must thus possess an efficient syste...

journal_title：Experimental parasitology

authors： Tröße C,Kongshaug H,Dondrup M,Nilsen F

更新日期：2015-10-01 00:00:00

abstract：:A series of novel hybrid 4-aminoquinoline 1,3,5-triazine derivatives was synthesized in a five-steps reaction and evaluated for their in vitro antimalarial activity against chloroquine-sensitive (3D7) and chloroquine-resistant (RKL-2) strains of Plasmodium falciparum. Entire synthetic derivatives showed higher antimal...

journal_title：Experimental parasitology

authors： Bhat HR,Singh UP,Thakur A,Kumar Ghosh S,Gogoi K,Prakash A,Singh RK

更新日期：2015-10-01 00:00:00

abstract：:Toxoplasmosis is a widely distributed disease caused by the protozoan Toxoplasma gondii that is mainly transmitted orally. Once ingested, the parasite crosses the intestinal barrier to reach the blood and lymph systems to migrate to other regions of the host. The objective of this study was to evaluate the changes in ...

journal_title：Experimental parasitology

authors： Vicentino-Vieira SL,Nogueira de Melo Gde A,Biondaro Góis M,Martins Moreira N,de Araujo Pereira LG,de Almeida Araújo EJ,Garcia JL,de Mello Gonçales Sant'Ana D

更新日期：2015-09-01 00:00:00

abstract：:In the search of new alternatives for neurocysticercosis treatment, the cysticidal activity of organic extracts of Teloxys graveolens was evaluated. The in vitro activity of hexane, ethyl acetate and methanol extracts against Taenia crassiceps cysts was tested and the selectivity index relative to human fibroblasts wa...

journal_title：Experimental parasitology

authors： Palomares-Alonso F,Rojas-Tomé IS,Juárez Rocha V,Palencia Hernández G,González-Maciel A,Ramos-Morales A,Santiago-Reyes R,González-Hernández IE,Jung-Cook H

更新日期：2015-09-01 00:00:00

abstract：:Balamuthia mandrillaris is a free-living ameba (FLA) that has been isolated or its DNA identified in soil, dust and water. It causes a fatal central nervous system infection in humans and animals. Although it is environmental as Acanthamoeba and Naegleria fowleri, the two other free-living amebae that also cause CNS i...

journal_title：Experimental parasitology

authors： Yera H,Dupouy-Camet J,Jackson JW,Sriram R,Sweat S,Goldstein JM,Visvesvara GS

更新日期：2015-09-01 00:00:00

abstract：:Enterocytozoon bieneusi is a zoonotic pathogen of the phylum Microspora that infects humans as well as a variety of animal species worldwide. While molecular epidemiologic studies have characterized this parasite in various hosts, isolates from many susceptible hosts have not yet been examined. In this study, E. biene...

journal_title：Experimental parasitology

authors： Zhang Z,Huang J,Karim MR,Zhao J,Dong H,Ai W,Li F,Zhang L,Wang R

更新日期：2015-08-01 00:00:00

abstract：:Haemonchus contortus is the most economically important blood feeding nematode parasite of sheep and goats all over the world. Enolase in helminth parasites is a multi-functional enzyme which involves in glycolysis and host tissue invasion. In this study, the recombinant H. contortus enolase (rHcENO) was evaluated for...

journal_title：Experimental parasitology

authors： Kalyanasundaram A,Jawahar S,Ilangopathy M,Palavesam A,Raman M

更新日期：2015-07-01 00:00:00

abstract：:The present study aimed to evaluate the acaricidal efficacy of fluazuron (2.5 mg/kg), administered as a pour-on, in comparison to an injectable formulation containing fluazuron (1.6 mg/kg) + ivermectin (0.63 mg/kg), against Rhipicephalus (Boophilus) microplus in naturally and experimentally infested cattle. Two studie...

journal_title：Experimental parasitology

authors： Gomes LV,Lopes WD,Cruz BC,Teixeira WF,Felippelli G,Maciel WG,Bichuette MA,Ruivo MA,Alcantara Colli MH,Carvalho RS,Martinez AC,Soares VE,da Costa AJ

更新日期：2015-06-01 00:00:00

abstract：:A cell-free culture system for Cryptosporidium parvum was analysed using scanning electron microscopy (SEM) to characterise life cycle stages and compare gene expression in cell-free culture and cell culture using HCT-8 cells. Cryptosporidium parvum samples were harvested at 2 h, 8 h, 14 h, 26 h, 50 h, 74 h, 98 h, 122...

journal_title：Experimental parasitology

authors： Yang R,Elankumaran Y,Hijjawi N,Ryan U

更新日期：2015-06-01 00:00:00

abstract：:Pyruvate kinase (PK; EC 2.7.1.40) and phosphoenolpyruvate carboxykinase (PEPCK; EC 4.1.1.32) are essential regulatory enzymes of glucose oxidation in helminths, the PK/PEPCK branch point being the first divergent step between carbohydrate catabolism of the parasites and their hosts. Recently, PEPCK from the cestode pa...

journal_title：Experimental parasitology

authors： Das B,Ramnath,Dutta AK,Tandon V

更新日期：2015-06-01 00:00:00

abstract：:Early diagnosis and determining the infective stage are critical for effective therapy of toxoplasmosis. Owing to the progress in biotechnology, commonly used native, non-standardized diagnostic antigens should be replaced by genetically engineered antigens. The recombinant proteins are also promising components of su...

journal_title：Experimental parasitology

authors： Grzybowski MM,Dziadek B,Dziadek J,Gatkowska J,Dzitko K,Długońska H

更新日期：2015-03-01 00:00:00

abstract：:Serine hydroxymethyltransferase belongs to the class of pyridoxal-5-phosphate enzymes along with aspartate aminotransferase. To explore the function of residue(s) involved in binding of the carboxylate group of Tetrahydrofolic acid (THF) to L. donovani cytosolic serine hydroxymethyltransferase (LdcSHMT), the gene was ...

journal_title：Experimental parasitology

authors： Gandhi S,Gaur N,Krishna S,Siddiqi MI,Saxena JK

更新日期：2015-02-01 00:00:00

abstract：:Baccharis dracunculifolia DC (common name "alecrim-do-campo" in Brazil) is a plant with widespread distribution in South America that is the botanical origin of green propolis. The aim of this study was to evaluate the chemical composition and acaricidal activity of the essential oil of B. dracunculifolia and its cons...

journal_title：Experimental parasitology

authors： de Assis Lage TC,Montanari RM,Fernandes SA,de Oliveira Monteiro CM,de Oliveira Souza Senra T,Zeringota V,da Silva Matos R,Daemon E

更新日期：2015-01-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) constitute a large family of Zn(2+) and Ca(2+) dependent endopeptidases implicated in tissue remodeling and chronic inflammation. MMPs also play key roles in the activation of growth factors, chemokines and cytokines produced by many cell types, including lymphocytes, granulocytes, and...

journal_title：Experimental parasitology

authors： de Pinho RT,da Silva WS,de Castro Côrtes LM,da Silva Vasconcelos Sousa P,de Araujo Soares RO,Alves CR

更新日期：2014-12-01 00:00:00

abstract：:In March 2010, a 35 year-old HIV/AIDS female patient was admitted to hospital to start treatment with Highly Active Antiretroviral Therapy (HAART) since during a routine control a dramatic decrease in the CD4(+) levels was detected. At this stage, a nasal swab from each nostril was collected from the patient to includ...

journal_title：Experimental parasitology

authors： Cabello-Vílchez AM,Mena R,Zuñiga J,Cermeño P,Martín-Navarro CM,González AC,López-Arencibia A,Reyes-Batlle M,Piñero JE,Valladares B,Lorenzo-Morales J

更新日期：2014-11-01 00:00:00

abstract：:Automated extraction of DNA for testing of laboratory samples is an attractive alternative to labour-intensive manual methods when higher throughput is required. However, it is important to maintain the maximum detection sensitivity possible to reduce the occurrence of type II errors (false negatives; failure to detec...

journal_title：Experimental parasitology

authors： Dunlop J,Thompson CK,Godfrey SS,Thompson RC

更新日期：2014-11-01 00:00:00

abstract：:Leishmaniasis, a neglected tropical disease (NTD) causes major health problems in the tropical and subtropical world. Most of the antileishmanial modern therapies with different formulations of pentavalent antimonials, Miltefosine, Amphotericin B etc. are not satisfactory in recent times due to high toxicity to the ho...

journal_title：Experimental parasitology

authors： Paik D,Das P,De T,Chakraborti T

更新日期：2014-11-01 00:00:00

abstract：:The excretory/secretory (ES) proteins of schistosomes play important roles in modulating host immune systems and are regarded as potential vaccine candidates and drug targets. Protein disulfide isomerase (PDI) is an essential enzyme that is involved in disulfide bond formation and rearrangement. In the present study, ...

journal_title：Experimental parasitology

authors： Cao X,Hong Y,Zhang M,Han Y,Wu M,Wang X,Guo X,Li C,Lu K,Li H,Fu Z,Lin J

更新日期：2014-11-01 00:00:00

abstract：:Toll-like receptors (TLRs) play a fundamental role in the rapid activation of innate immune responses to a variety of pathogen-associated molecular patterns (PAMPs). In a previous study we observed an increase in the level of expression of TLR2 and TLR4 mRNA in the jejunum and colon during experimental hymenolepidosis...

journal_title：Experimental parasitology

authors： Kosik-Bogacka DI,Wojtkowiak-Giera A,Kolasa A,Baranowska-Bosiacka I,Lanocha N,Wandurska-Nowak E,Izabela G,Salamatin R,Jagodzinski PP

更新日期：2014-10-01 00:00:00

abstract：:We here describe the novel finding that brain endothelial cells in vitro can stimulate the growth of Plasmodium falciparum through the production of low molecular weight growth factors. By using a conditioned medium approach, we show that the brain endothelial cells continued to release these factors over time. If thi...

journal_title：Experimental parasitology

authors： Khaw LT,Ball HJ,Mitchell AJ,Grau GE,Stocker R,Golenser J,Hunt NH

更新日期：2014-10-01 00:00:00

abstract：:The effect of experimental exposure of Bradybaena similaris by Eurytrema coelomaticum on the cholesterol and triglycerides total levels circulating in the hemolymph and the neutral lipids in the digestive gland-gonad (DGG) complex of the host snail were studied. In this study, snails were dissected after one, two, and...

journal_title：Experimental parasitology

authors： Alves H,Tunholi-Alves VM,Tunholi VM,Gôlo P,Bittencourt VR,Pinheiro J

更新日期：2014-09-01 00:00:00

abstract：:Previously generated two auxotrophic genes knockout Edwardsiella tarda (Δalr Δasd E. tarda) was used as a delivery vehicle for CpG 1668 motif-enriched plasmids (pL-CpG30), and potential of the Δalr Δasd E. tarda-mediated delivery of CpG motifs in both prevention and therapeutic treatment of scuticociliatosis caused by...

journal_title：Experimental parasitology

authors： Kang YJ,Choi SH,Kim KH

更新日期：2014-09-01 00:00:00

abstract：:The aim of this study was to evaluate the effects of selenium and copper on oxidative stress and its performance in lambs experimentally infected with Haemonchus contortus. Twenty-eight five-months old lambs were experimentally infected by the oral route with 5000 third-stage infective larvae and allocated into four g...

journal_title：Experimental parasitology

authors： Leal ML,Pivoto FL,Fausto GC,Aires AR,Grando TH,Roos DH,Sudati JH,Wagner C,Costa MM,Molento MB,da Rocha JB

更新日期：2014-09-01 00:00:00

abstract：:Traditional classification of Demodex mites by hosts and phenotypic characteristics is defective because of environmental influences. In this study, we proposed molecular identification of four phenotypes of two human Demodex species based on mitochondrial cox1 fragments for the first time. Mites collected from suffer...

journal_title：Experimental parasitology

authors： Hu L,Zhao YE,Cheng J,Ma JX

更新日期：2014-07-01 00:00:00

abstract：:Microtus fortis is a non-permissive host for Schistosoma japonicum. While M. fortis lymphocytes are known to provide natural resistance against S. japonicum, the specific mechanism remains unclear. A bone marrow transplantation (BMT) model was established using immunodeficient mice, either nude (experiment 1) or V(D)J...

journal_title：Experimental parasitology

authors： Hu Y,Xu Y,Lu W,Quan H,Shen Y,Yuan Z,Zhang J,Zang W,He Y,Cao J

更新日期：2014-07-01 00:00:00

abstract：:The population structure of original Babesia bigemina isolates and reference strains with a defined phenotypic profile was assessed using 18S rRNA and rap-1c genes. Two reference strains, BbiS2P-c (virulent) and BbiS1A-c (low virulence), were biologically cloned in vitro. The virulence profile of the strains and clone...

journal_title：Experimental parasitology

authors： Thompson C,Baravalle ME,Valentini B,Mangold A,Torioni de Echaide S,Ruybal P,Farber M,Echaide I

更新日期：2014-06-01 00:00:00

abstract：:Plasmodium falciparum is usually asynchronous during in vitro culture. Highly synchronized cultures of P. falciparum are routinely used in malaria research. Here, we describe a simple synchronization procedure for P. falciparum asexual erythrocytic culture, which involves storage at 4°C for 8-24 h followed by routine ...

journal_title：Experimental parasitology

authors： Yuan L,Hao M,Wu L,Zhao Z,Rosenthal BM,Li X,He Y,Sun L,Feng G,Xiang Z,Cui L,Yang Z

更新日期：2014-05-01 00:00:00

abstract：:Few studies have investigated Toxoplasma gondii infections in bat populations and none have reported its presence in protected British bat species. Using a collection of dead/euthanased bats collected from Lancashire, UK, two species of bats (Pipistrellus pipistrellus and Pipistrellus pygmaeus) were tested using a hig...

journal_title：Experimental parasitology

authors： Dodd NS,Lord JS,Jehle R,Parker S,Parker F,Brooks DR,Hide G

更新日期：2014-04-01 00:00:00

abstract：:Improved methods for efficient excystation of Eimeria should be developed and standardized for future Eimeria-related studies. Here, the effects of different glass bead sizes (0.5, 1, 2, and 2.5 mm), and various vortex speeds (1000, 2000, and 3000 rpm) and durations (30 s, 1, 3, and 5 min) have been examined for Eimer...

journal_title：Experimental parasitology

authors： Cha JO,Talha AF,Lim CW,Kim B

更新日期：2014-03-01 00:00:00

abstract：:Proteins belonging to the serine protease inhibitor (serpin) superfamily play essential roles in many organisms. In arthropods these proteins are involved in innate immune system, morphogenesis and development. In mammals serpins regulate pathways that are essential to life such as blood coagulation, fibrinolysis, inf...

journal_title：Experimental parasitology

authors： Tirloni L,Seixas A,Mulenga A,Vaz Ida S Jr,Termignoni C

更新日期：2014-02-01 00:00:00

abstract：:Recent epidemiological evidences revealed the higher prevalence of 'O' blood group in the residents of malaria-endemic areas. Also some data indicated preference of mosquitoes to 'O' group. The aim of this study was to determine ABO group ratio in the residents as well as ABO group preference of Anopheles in two malar...

journal_title：Experimental parasitology

authors： Anjomruz M,Oshaghi MA,Sedaghat MM,Pourfatollah AA,Raeisi A,Vatandoost H,Mohtarami F,Yeryan M,Bakhshi H,Nikpoor F

更新日期：2014-01-01 00:00:00

abstract：:Molecular characterizations of Cryptosporidium spp. in dairy cattle in industrialized nations have mostly shown a dominance of Cryptosporidium parvum, especially its IIa subtypes in pre-weaned calves. Few studies, however, have been conducted on the distribution of Cryptosporidium species and C. parvum subtypes in var...

journal_title：Experimental parasitology

authors： Amer S,Zidan S,Adamu H,Ye J,Roellig D,Xiao L,Feng Y

更新日期：2013-11-01 00:00:00